The microduplication at 4p13.1 intersected with the LPHN3. Variants of LPHN3 were associated with attention deficit hyperactivity disorder, autism spectrum disorder, and substance use disorder (Martinez et al., 2016; Arcos-Burgos et al., 2019; Kappel et al., 2019). This evidence concerns the gene ADGRL3 and attention deficit-hyperactivity disorder.