Once derailed, hyperactive macrophages secrete high levels of IFN‐γ, IP-10 (IP‐10), IL-6, IL-17, TNF-α along with TGF-β and IL-10/23, leading to the Th2/Th17 programming in the infected lungsof severe cases of COVID-19 (6). This evidence concerns the gene CXCL10 and COVID-19.