Using methionine/choline-deficient diet (MCD) or high-fat diet (HFD) as murine models of non-alcoholic steatohepatitis (NASH), it was shown that STING/IRF3 pathway promotes hepatocyte injury and dysfunction by inducing inflammation and apoptosis as well as by disturbing glucose and lipid metabolism (110). The gene discussed is IRF3; the disease is metabolic dysfunction-associated steatohepatitis.