The downregulation of CD83 on DCs resulted in a lower stimulatory capacity (39); therefore, we can speculate that, despite the high expression of HLA-G, DC-10 in Abpos FDRs and in T1D patients are poorly activated and might have an impaired ability to activate and/or induce regulatory T cells. This evidence concerns the gene FBXO8 and type 1 diabetes mellitus.