According to previous data (27, 28), the frequency of CD11c+HLA-DR+ myeloid DCs was reduced in T1D patients (36.60% ± 10.15%) compared with that present in HCs (47.06% ± 13.45%, p = 0.0107) and in Abneg FDRs (46.86% ± 14.00%, p = 0.0424) but was similar to that observed in Abpos FDRs (38.13% ± 14%) (Supplementary Figure S3B and Supplementary Table S2). The gene discussed is ITGAX; the disease is type 1 diabetes mellitus.