CLEC4D and colonic neoplasm: In particular, Dectin-3 receptors recognize α-mannans on the surface of multiple fungi such as C.albicans, Paracoccidioides brasiliensis, and Cryptococcus. Interestingly, Dectin-3−/− mice have recently been found to present enhanced colitis-associated colon cancer (CAC) correlating with an increase in the C. albicans burden.