Hence, the TWEAK/Fn14 signaling pathway contributes to promote inflammation in different tissues, reason for which the exacerbated or persistent upregulation of this pathway has been demonstrated to play a crucial role in the pathogenesis of some autoimmune/inflammatory diseases such as SLE and RA (6, 56, 57). The gene discussed is TNFRSF12A; the disease is rheumatoid arthritis.