CD40LG and common variable immunodeficiency: Polyclonal stimulations composed of Staphylococcus aureus Cowan I (SAC), poke weed mitogen (PWM) and oligonucleotides with cytosine and guanin motives (CpG) or CD40L, (IL-21) and CpG that were used in this study have been shown to recover B cell functions in other B cell deficiencies including common variable immunodeficiency (CVID) and systemic autoimmune diseases (25, 26)[Steiner et al.