TLR8 and lung carcinoma: proposed that oncogenic genes miR-21 and miR-29a excreted by exosomes derived from lung cancer cells were able to combine TLR with mouse (TLR7) and human (TLR8), resulting in TLR-mediated NF-κB activation and secretion of the prometastatic inflammatory cytokines TNF-α and IL-6 (53).