As the infection progresses, B cells react to the increased IFN-γ secretion by upregulating the expression HLA-G (e.g., HLA-G1 & HLA-G5), leading to decreases on CD85j, which in turn limits the production of IFN-γ by MAIT cells, maintaining homeostasis, and avoiding dysregulated host responses. This evidence concerns the gene IFNG and infection.