IRF1 and granular corneal dystrophy type II: Ingenuity Pathway Analysis determined that the IL-15 production pathway was one of the top potential pathways found to be upregulated in both NHEKs and THP-1 cells treated with recombinant human IL-27 (rhIL-27) as well as in human ACD samples from 96 hours after epicutaneous challenge (adjusted p-value = 0.0014, IL15, STAT1, and IRF1) (Figure 5A, and data not shown).