First, we identified through biocomputational analyses differentially expressed genes (DEGs) from 3 microarrays: 1) DEGs between vehicle and IL-27-treated THP-1 cells (GSE143228) 2) DEGs from normal human epidermal keratinocytes (NHEK) treated with vehicle or IL-27 (GSE143228), and 3) DEGs from patch-test positive ACD patient samples compared to the skin at 0 hr (GSE6281; also shown in Figure 2A) (Figure 5A). This evidence concerns the gene IL27 and granular corneal dystrophy type II.