However, the splenomegaly in Ifnar1-/- mice subsisted in eosinophil depleted mice (Figure 6F) and percentages of CD8+ T cells in spleens of PbA-infected and eosinophil depleted Ifnar1-/- mice remained similar to infected Ifnar1-/- mice that received isotype control antibodies (Figure 6G). The gene discussed is CD8A; the disease is Splenomegaly.