It was noticed that the percentage of CD3+TIGIT+ T(53.89 ± 14.05), CD4+TIGIT+ T(54.88 ± 18.56) and CD8+TIGIT+ T cells (52.03 ± 7.65) were significantly increased in tumor tissues when compared with peripheral blood samples (Figures 1A, B). The gene discussed is CD4; the disease is neoplasm.