CXCL8 and infection: TLR activation leads to an increase of IL-12, IL-6, IL-8, and TNF-α cytokines, chemokines (CCL5, CCL12, and XCL1), interferons (IFNs), and other effector molecules such as NO, which favors infection control (Yarovinsky and Sher, 2006; Wujcicka et al., 2013).