During the 5-year period within T2D, group 1 (Q1; n=23) increased their PA levels and insulin sensitivity, group 2 (Q2; n=8) decreased PA levels and worsened fasting blood glucose, group 3 (Q3; n=26), decreased both insulin sensitivity and PA levels and group 4 (Q4; n=37) and increased PA levels without any improvement in insulin sensitivity. Here, INS is linked to type 2 diabetes mellitus.