Partially characterized antibodies in 2004 included ANNA-3, a very rare reactivity reported in some cases of sensory, sensorimotor and autonomic neuropathy (21), anti-Zic4—a marker of cerebellar degeneration described in some cases of neuropathy, usually with concomitant antibodies (anti-Hu and/or anti-CV2) (22)—and anti-PCA2, which in the earlier large case series (23) was described in both central and peripheral syndromes, including LEMS and neuropathy. This evidence concerns the gene ZIC4 and neuropathy.