FMR1 and fragile X syndrome: In a recent paper evaluating a cohort of male and female patients with FXS, male children carrying full FMR1 mutation and expressing some degree of FMR1 mRNA due to incomplete methylation had significantly higher Autism Diagnostic Observational Schedule (ADOS) severity scores, compared to individuals with FXS carrying full FMR1 mutation but with completely silenced FMR1.