- ↓ lung induced oxidative stress (↓ ROS and LPO) - Restores the reduced activities of the phase II enzymes NQO1 and GST induced by the BLM - ↓ pulmonary inflammation (NF-κB, IL-1β, TNFα) - ↓ pulmonary damages and ↓ the lung collagen and hydroxyproline content. The gene discussed is IL1B; the disease is inflammatory response.