GSR and infection: Administered after the NTHI infection it attenuates the lung inflammation in treated mice and it up-regulates the translocation of Nrf2 into the nucleus, enhances HO-1, glutathione reductase (GSR), GCLM, glutathione peroxidase-2 (GPx-2), and NQO1 gene expression in the lungs (Table 1; Tan et al., 2016).