NFE2L2 and acute respiratory distress syndrome: In a mouse model of ARDS induced by LPS, SFN was shown to inhibit the increase of NF-κB, prevent increases in several proinflammatory mediators and enzymes cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) as well as activating the Nrf2 pathway (Qi et al., 2016).