- ↓ lung induced oxidative stress (↓ MDA and MPO in the BAL and in the whole lung - ↓ collagen deposition assessed by hydroxyproline content, pulmonary fibrosis and ↓ level of TGF1β - ↓ pulmonary inflammation (↓ NF-κB-p65 nuclear translocation, IκB Ser32/36 phosphorylation). The gene discussed is MPO; the disease is pulmonary fibrosis.