In macrophages from COPD subjects: - ↑ bacterial clearance of PA and NTHI through an enhancement of phagocytosis- ↑ increase the expression of the scavenger receptor MARCO In mouse model: - ↓ the bacterial burden and ↑ the phagocytosis of macrophage in Nrf2+/+ but not in Nrf2–/– mice. Here, GABPA is linked to chronic obstructive pulmonary disease.