β-catenin GOF in LSECs did not significantly regulate GATA4 expression, which most likely protects against a complete capillarization program and perisinusoidal liver fibrosis by suppressing pro-fibrotic angiocrine factors such as Pdgfb, which was unaltered in Ctnnb1OE−EC LSEC despite a significant Myc induction. Here, MYC is linked to Hepatic fibrosis.