This sinusoidal transformation in the fetal liver inhibited homing of hematopoietic stem and progenitor cells into the fetal liver resulting in fatal anemia (Geraud et al., 2017), while Gata4 deletion in the mature vasculature caused hepatopathy and perisinusoidal liver fibrosis (Winkler et al., 2021). Here, GATA4 is linked to Hepatic fibrosis.