Previous work by us could show, that loss of LSEC master regulator GATA4 also induced pro-angiogenic Myc in LSECs, to further amplify a pro-fibrotic angiocrine program, including de novo Pdgfb expression, resulting in perisinusoidal liver fibrosis (Winkler et al., 2021). The gene discussed is MYC; the disease is Hepatic fibrosis.