Yet, one has to consider that aberrant Apln expression is also found in CD34+ capillarized LSECs in liver fibrosis (Winkler et al., 2021) and cirrhosis (Yokomori et al., 2012) and also pro-angiogenic effects were similar to the vascular apelin signaling (Helker et al., 2020). The gene discussed is APLN; the disease is Hepatic fibrosis.