Sphingosine kinase 2 (SphK2), which, unlike its more extensively studied isoform SphK1, additionally possesses a nuclear localization signal (NLS) and a nuclear export signal (NES), was observed to co-localize with the replication complex of Chikungunya virus and pharmacological inhibition of its kinase activity reduced viral infection (Reid et al., 2015). The gene discussed is SPHK2; the disease is viral infectious disease.