TGF-β2/Smad signaling (McDowell et al., 2013), Wnt/β-catenin signaling (Villarreal et al., 2014), and several biomolecular factors, such as connective tissue growth factor (Kuespert et al., 2015), MMPs, and TIMPs (Helin-Toiviainen et al., 2015), have been reported to play significant roles in the regulation of ECM remodeling in glaucoma. Here, CCN2 is linked to glaucoma.