Until now, numerous kidney diseases, including AKI, diabetic nephropathy (DN), and chronic kidney disease (CKD) are proved to be associated to the abnormal of NOX2/4 expression and ROS level (Babelova et al., 2012; Gorin and Block, 2013; Thallas-Bonke et al., 2015; Meng et al., 2018). The gene discussed is CYBB; the disease is acute kidney injury.