HIF1A and cancer: Mechanically, it exerts anticancer effects through cancer cell proliferation inhibition via EGFR/mTOR signaling pathway, through cell death induction via calcium-dependent ROS production or through epithelial-mesenchymal transition (EMT) suppression via blocking the HIF-1α activation of PI3k/Akt signaling pathway (Lee et al., 2011; Ni et al., 2014; Deng et al., 2019).