TRPM8 and epilepsy: In WT mice, EDs were focally induced by epilepsy-inducer, and were rarely propagated in the contralateral side (Figures 2B–E, p = 0.035, p = 0.064, respectively, Welch’s t-test; Figure 2I), whereas the EDs were easily propagated in the contralateral side by the lack of TRPM8 channels (Figures 2F,G, p = 0.003, p = 0.015, respectively, Welch’s t-test; Figure 2I).