F2R and Sepsis: Among the four identified types of PARs (PAR-1 to PAR-4), PAR-1 is essential for the regulation of endothelial barrier function and proinflammatory factor release and mediates the interplay between coagulation and inflammation in various inflammatory conditions, including sepsis, multiple sclerosis, and ALI (Chambers, 2008; Chambers and Scotton, 2012; Kim et al., 2015; Li et al., 2020).