AKT1 and Thrombocytopenia: Figures 5G,H revealed that CBZ-induced apoptotic events were moderately reduced in Akt-deficient platelets, which further confirms that CBZ induces platelet apoptosis at least partly through PI3K/Akt pathway. We next assessed the effect of Akt on thrombocytopenia induced by CBZ in vivo. Consistent with in vitro data, Figures 5I,J showed that CBZ-induced thrombocytopenia and platelet clearance were slightly reduced in the Akt−/− mice.