HDAC3 interacts with Myc through the MBIIIa domain (Kurland and Tansey, 2008), and subsequently reduces miR-15a/16-1 level in mantle cell lymphoma (MCL) by anchoring at the two promoters of the miR-15a/16-1 cluster gene, DLEU2, and exerting repressive function (Zhang et al., 2012). The gene discussed is HDAC3; the disease is mantle cell lymphoma.