CD274 and renal cell adenocarcinoma: ICIs including CTLA-4 (ipilimumab), PD-1 (nivolumab or pembrolizumab), and PD-L1 (atezolizumab, avelumab, or durvalumab), either as a monotherapy or combination therapy can induce tumor responses in melanoma, non-small cell lung cancer (NSCLC), renal cell cancer (RCC), head and neck squamous cell carcinoma, urothelial cancer, breast cancer and Hodgkin disease (Ribas and Wolchok, 2018).