MAPT and Alzheimer disease: AD is one of the most common neurodegenerative disorders, characterised by a progressive memory decline, cognitive impairment, amyloid β1-42 (Aβ) plaque accumulation, neurofibrillary tangle of hyperphosphorylated tau (p-tau) protein and occurrence of neurogenic/inflammatory responses in the central nervous system (Scheltens et al., 2016).