IL1B and Alzheimer disease: In accordance with this evidence, SAMP8 mice were associated with an increased colonic concentration of IL-1β and glial hyperactivation along with an impairment of IEB, as documented by a decreased expression of tight junction proteins and an increment in circulating LPS levels (regarded as an indirect index of intestinal permeability), suggesting an impairment of IEB in concomitance with enteric phlogistic process in early AD animals.