The immunological profile of AD patients shows a marked Th2 inflammation in all the subtypes, as shown by frequencies of IL-13+ and IL-4+ T-cells (Esaki et al., 2016b), while Th22 inflammation increased from infancy to adulthood, as shown by high levels of IL-22 in adult AD in comparison to infancy AD (Czarnowicki et al., 2020). Here, IL22 is linked to Alzheimer disease.