To understand the reasons for the discrepancy of the effects of compound 23 between solid tumors and hematologic tumors, we identified the gene expression levels of kinases in the PI3K/Akt/mTOR axis and HDAC pathway, such as PI3Kα, Akt, S6, HDAC1, and TuBulin1α, through the CCLE database (https://portals.broadinstitute.org). The gene discussed is HDAC1; the disease is hematopoietic and lymphoid cell neoplasm.