In summary, compound 23, with a six alkyls linker and fluorine iodide in position 8 of quinazoline, showed its synergistic effect by simultaneously regulating PI3K and HDAC signaling pathways to significantly inhibit the proliferation of hematologic tumor cells and induce apoptosis and G1 arrest in vivo or in vitro. The gene discussed is HDAC9; the disease is neoplasm.