Kv1.3 plays a key role in pathogenesis of autoimmune diseases, e.g., multiple sclerosis, rheumatoid arthritis, and type-1 diabetes by triggering the activation and proliferation of T effector memory (TEM) cells (Chandy et al., 2004; Beeton et al., 2011a; Lam and Wulff, 2011; Chi et al., 2012; Toldi et al., 2013; Koshy et al., 2014). Here, KCNA3 is linked to autoimmune disease.