EIF4EBP1 and bronchiolitis obliterans syndrome: We found that BO treatment when accompanied with the regulation on amino acid metabolism promoted the phosphorylation of S6 and 4E-BP1, rather than those of PI3K, Akt, or mTOR, indicating that mTOR was activated by BO in an amino acid–regulated form, which correspondingly restrained autophagy to suppress tumor growth.