PLAT and ischemic stroke: Till 1995, NBP was found to be useful for ischemic stroke and later experiments showed that both injecting NBP 3 h before or 2 h after surgery had improvement on infarction volume and motor functional recovery, and clinical studies showed that patients using NBP alone had better neurological function than control groups; however, there was no significant difference for the efficacy between NBP and tPA, so NBP had been used for stroke treatment in China (Xu et al., 2019).