Till 1995, NBP was found to be useful for ischemic stroke and later experiments showed that both injecting NBP 3 h before or 2 h after surgery had improvement on infarction volume and motor functional recovery, and clinical studies showed that patients using NBP alone had better neurological function than control groups; however, there was no significant difference for the efficacy between NBP and tPA, so NBP had been used for stroke treatment in China (Xu et al., 2019). The gene discussed is PLAT; the disease is stroke disorder.