Astrocytes are activated during stroke and play a protective role for infarction and neurovascular recovery via secreting nutritional factors, as indicated by Pei et al.; astrocyte-derived exosomes inhibited the apoptosis and pro-inflammation factors in neuron cells, also autophagy-associated proteins such as P62 and LC3 were increased after exosomes in stroke model mice (Pei et al., 2019). This evidence concerns the gene MAP1LC3A and Stroke.