ICAM1 and atherosclerosis: During atherosclerosis initiation/progression and under the influence of inflammatory stimuli, the splenic monocytes are recruited to the atherogenic vessel wall via the systemic circulation, where they adhere and enter the arterial vessel wall through the activated endothelial cells via binding to the specific adhesion molecules, such as VCAM-1, ICAM-1, P-selectin, and E-selectin (Fayad et al., 2018).