Increased levels of ceramides (CER), especially CER (16:0), CER (18:0), CER (20:0), CER (22:0), CER (24:0), and CER (24:1) (Shah et al., 2008; Boini et al., 2010), as well as sphingomyelins, especially SM (16:0), SM (18:0) and SM (18:1) (Park et al., 2013), were found in plasma and organs such as liver, skeletal muscle, and heart, which contributes to insulin resistance. Here, CBLN1 is linked to Insulin resistance.