However, this effect varied according to cell type: immortalized cells derived from normal tissues and some cancer cell lines (e.g., cervix adenocarcinoma cells HeLa, skin melanoma cells A375 and WM-266-4) were resistant to DNA re-replication induced by GMNN knockdown (Zhu and Depamphilis, 2009). Here, GMNN is linked to cervical adenocarcinoma.