The upregulation of geminin in various malignancies was shown to be correlated with tumor cell proliferation, invasion, and metastasis (Gonzalez et al., 2004; Petropoulou et al., 2008; Emmett and O’Shea, 2012; Rajan et al., 2013; Sato et al., 2013; Hills and Diffley, 2014; Yagi et al., 2014; Zhang et al., 2017; Ryan et al, 2019; Alaeddini and Etemad-Moghadam, 2020; Lewis and Stracker, 2021). This evidence concerns the gene GMNN and neoplasm.