GMNN and gastric cancer: Two days after transfection with siGEM, the proportion of gastric cancer cells MKN45 and BGC-803 in the S + G2/M phase was increased compared to the cells transfected with a control siRNA (siGL) (Figures 2A,D), and it was accompanied by an increase in the number of giant nuclei observed by laser scanning confocal microscopy (Figures 2B,E) and downregulation of geminin expression (Figures 2C,F).