MAPT and Alzheimer disease: At present, the pathogenesis of AD has not been clearly clarified, and the common features for the clinical diagnosis of AD are senile plaques (SPs) from extracellular β-amyloid (Aβ) deposits and intraneuronal neurofibrillary tangles (NFTs) due to the aggregated and hyperphosphorylated Tau protein (Khan et al., 2020).