Since acetylation inhibits the binding of Tau to microtubules, enhances Tau accumulation by suppressing Tau degradation, and affects the structure and function of neurons in Tau overexpression models such as C. elegans single-copy transgenic model (Guha et al., 2020a,b), the activation of SIRT1 can promote the deacetylation of Tau protein, suggesting that targeting SIRT1 activation can serve as an effective strategy for the prevention and mitigation of AD. This evidence concerns the gene MAPT and Alzheimer disease.