Increasing evidence suggests that an increase in the number of mtDNA mutations in the frontotemporal lobes of the brain in AD patients is consistent with the increase in Aβ42 and hyperphosphorylated Tau in the cerebrospinal fluid, which further confirms the increased mtDNA mutation is associated with the deposition of Aβ in the brain (Podlesniy et al., 2013). The gene discussed is MAPT; the disease is Alzheimer disease.