Furthermore, another study has verified that voluntary wheel running for 5 months can increase the expression of Beclin1 and Atg5 in the cerebral cortex and hippocampus of both 7- and 1-month-old TgCRND8 (expressing a mutant human APP695 gene) mice, thereby suppressing the Aβ deposition in the brain of AD mice (Herring et al., 2016). The gene discussed is BECN1; the disease is Alzheimer disease.