MAPT and Alzheimer disease: In addition, 4-week treadmill exercise can significantly promote the neurogenesis of streptozotocin (STZ)-induced AD model rats, accompanying with reduced 4-HNE, DNA double-strand breaks (p-H2AX), and 8-OHdG, as well as reduced Aβ aggregation and hyperphosphorylated Tau protein in the brain (Lu et al., 2017).