MAPT and Alzheimer disease: Another previous study through 3xTg-AD mice for 3-month voluntary wheel running has documented that exercise can significantly reduce Aβ deposition and Tau hyperphosphorylation, reduce oxidative indicators such as glutathione disulfide (GSSG), and improve SOD activity in the hippocampal tissue, suggesting that exercise can improve redox status, reduce Aβ accumulation and Tau hyperphosphorylation and enhance brain memory function (García-Mesa et al., 2016).