Regarding neurodegenerative diseases, decreased striatal RGS2 expression was found in Huntington’s disease patients (Seredenina et al., 2011), and the observed altered expression of RGS2 mRNA levels in the striatum of rats undergoing dopamine depletion suggested a role in Parkinson’s disease (PD; Geurts et al., 2003). Here, RGS2 is linked to juvenile Huntington disease.