Our data showed significantly lower levels of BMAL1 (P < 0.0001), CLOCK (P < 0.01), CRY1 (P < 0.01), PER1 (P < 0.05), and PRY2 (P < 0.01) in PD than those in HC (Figures 1A–E). The gene discussed is CRY1; the disease is Parkinson disease.