Apolipoprotein E (APOE) is the most common genetic risk factor for late onset AD (Mahley et al., 2006; Peskind et al., 2009; Holtzman et al., 2012; Huang and Mucke, 2012; Riedel et al., 2016; Liu et al., 2019; Paranjpe et al., 2019a). This evidence concerns the gene APOE and Alzheimer disease.