ITPKB and Alzheimer disease: Our brain transcriptome findings for females with AD, including downregulation of autophagy and proteolysis pathways, upregulation of pathways related to the immune system and HSV infection, as well as ITPKB as a hub gene, particularly in female APOE ε4 carriers, highlight specific gene-encoded processes in the brain that may be more involved in AD for women than for men.