Rapamycin’s inhibitory effect on mTOR activity and subsequently mossy fiber sprouting has been demonstrated numerous times using various models of epilepsy (Zeng et al., 2009; Huang et al., 2010; Tang et al., 2012; van Vliet et al., 2012; Guo et al., 2013; Yamawaki et al., 2015; Hester et al., 2016). The gene discussed is MTOR; the disease is epilepsy.