Dossi and Blauwblomme (2018) found that the Panx1 channel promotes the origination and preservation of epilepsy through ATP signaling via purinergic 2 receptors. In addition, Panx1 expression was detected to be positively correlated with the seizure frequency in patients with FCD (Li et al., 2017). In comparison to Panx2, the expression of Panx1 protein is significantly increased in the temporal cortex of TLE patients than the normal group, indicating that the Panx1 channel may be involved in the pathogenesis of TLE (Jiang et al., 2013). This evidence concerns the gene PANX1 and epilepsy.