In a 6-OHDA model of Parkinson’s disease, it was demonstrated that administration of Sig-1R agonists afobazole or PRE-084 over 2 weeks significantly restores the motor deficits and inhibit decreases of dopamine in the 6-OHDA-lesioned striatum, whereas these protective effects were blocked by antagonists BD-1047 (Voronin et al., 2019; Kadnikov et al., 2020). The gene discussed is SIGMAR1; the disease is Parkinson disease.