LRRK2 and Parkinson disease: In addition, in PD, LRRK2 mutations induce cell death by activating kinase activity (Greggio et al., 2006) or microtubule-associated neurotoxicity and neurodegeneration by oligomerizing LRRK2 (Kett et al., 2012; Dhekne et al., 2018; Watanabe et al., 2020).