ACE2 and Alzheimer disease: In 5-month-old OXYS rats that correspond to an early stage of AD-like progression, our group revealed novel targets of CEF as it modulated the expression of genes related to the system of Aβ metabolism in the brain, namely, it affected mRNA levels of Bace1, Ace2, Mme, Ide, Ece1, and Epo (Tikhonova et al., 2018).