TREM2 and Alzheimer disease: Complement cascade and TREM2/TYROBP inferences from our study were validated in integrative computational AD literature and in literature oriented toward LOAD (Cribbs et al., 2012; Schafer et al., 2012; Zhang et al., 2013; Hong and Stevens, 2016; Hong et al., 2016; Keren-Shaul et al., 2017; Gratuze et al., 2018; Bartels et al., 2020).