After acupuncture treatment in the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis or ileitis model, the level of TNF-α, IL-1β, and IL-6 and disease activity index, microscopic changes scour, and MPO level were decreased and caused to attenuate VH, and weight gain was improved (Tian et al., 2003; Kim et al., 2017; Shah et al., 2020). This evidence concerns the gene IL6 and Crohn ileitis.