EPAS1 and neoplasm: We next considered whether this expression pattern extended to other genes which were dysregulated in AMs with loss of Phd2. The following genes were selected for analysis: Hif-2α, since its upregulation is characteristic of VHL-associated neoplasia including PCCs (Toledo 2017); Vegfa and Rgs5, since these are reported HIF target genes (Jin et al. 2009, Fielding et al. 2018) and the latter is also a proposed regulator of chromaffin cell differentiation (Chan et al. 2019, Hanemaaijer et al. 2021).