GRIA1 and Anxiety: To further validate our SEP-GluA1 knockin line, we conducted a battery of behavioral experiments as GluA1 knockout mice show deficits in several behaviors, including locomotor activity, anxiety, and spatial memory (Bannerman et al., 2004; Boerner et al., 2017; Bygrave et al., 2019; Sanderson et al., 2007).