These two patients did not show any signs of cryoglobulinemia-related clinical manifestations or kidney pathological characteristics and showed strong C3 deposition with little immunoglobulins on IF, granular dense deposits on multiple areas which indicated that they were more consistent with C3 glomerulonephritis instead of cryoglobulinemic glomerulonephritis. The gene discussed is C3; the disease is cryoglobulinemia.