GK and Hypokalemia: Although the number of K+ channels whose possible K+-dependent stability has been study is still small, conditions in which GK loss by hypokalemia may be related to a pathological condition had already been reported, for example:As mentioned before, intracellular channel blockers of clinical use, like the antiarrhythmic quinidine may cause the GK collapse of delayed rectifier K+ channels, like Shab or the squid channel, under, extracellular, hypokalemic conditions [36,37].