TTR and carpal tunnel syndrome: However, as odds ratios (TTR-positive over TTR-negative) were still >1 for 20 of the 26 symptoms [e.g. anaemia, history of carpal tunnel syndrome, diarrhoea, dyshidrosis, abnormal (fluttering) heartbeat, and unintentional weight loss], we also compared the average number of symptoms per subject between the groups.